Chromatography polishing: Challenges, shifts, and solutions

As upstream processes become more intensified and antibody formats continue to diversify, chromatography polishing is facing new challenges. In this panel discussion, Cytiva experts explore how increasing titers, more complex molecules, and evolving impurity profiles are changing the role of polishing in downstream processing.

The discussion covers key questions including:

- When does polishing become a bottleneck?
- Why can’t polishing always follow the same intensification strategies as capture?
- What are the opportunities and limitations of flow-through polishing?
- How are bispecific and multispecific antibodies changing impurity removal needs?
- Why are selectivity, resin screening, and process development tools becoming more important?
- How could mechanistic modeling, machine learning, and AI help guide future process development?

This session was broadcast in May 2026 during the Process development virtual summit.

Expert speakers:

- Henrik Ihre, Ph.D., Distinguished Fellow
- Eva Heldin (Principal Scientist),
- Niklas Jungnelius (Director of Process Modeling),
- Jakob Liderfelt (Global Program Leader)