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Optimizing and standardizing the cryopreservation of cellular samples

New data and insights from the UK’s Advanced Therapy Treatment Centres program
The Advanced Therapy Treatment Centres (ATTC) network program— coordinated by the UK’s Cell and Gene Therapy Catapult (CGT Catapult)—addresses the complex challenges of bringing pioneering Advanced Therapy Medicinal Products (ATMPs) to patients. The ATTC networks look at standardizing cryogenic cold chain processes for cell therapies, with the aim to develop robust systems for the routine delivery of ATMPs throughout the UK’s NHS. Successful cryopreservation is a crucial step in manufacturing effective clinical delivery. It also provides a commercially robust business model for ATMPs. The vital parameters to consider for successful cryopreservation include the:

• application of an optimal cooling rate
• use and careful addition of an adapted cryoprotective solution
• choice of the cooling unit (controlled-rate freezer)
• end-to-end traceability of cryopreserved starting material/product
• minimization of contamination risk
• reproducibility of the cryopreservation process

This webinar takes a deep dive into the challenges of cryopreserving ATMP starting material and final therapy. Plus, we discuss how a liquid nitrogen-free controlled rate freezer can help you achieve successful cryopreservation of different cellular therapy products.

Hear insights from industry leaders—including, Sandeep Kumar, Cell Therapy Advanced Specialist for NHSBT, UK and Dr. Julie Meneghel, Cytiva—about new research findings from the UK National Health Service Blood and Transplant (NHSBT).

What you will learn:
• The post-thaw outcome of a range of therapeutically relevant cell types—from stem cells to T cells—and their differential robustness to cryopreservation
• The pros and cons of LN2 and LN2-free technologies for the cryopreservation of ATMP starting material and final product from NHSBT’s perspective
• The importance of cooling and warming rates for a successful cell cryopreservation outcome
• The importance of sample volume considerations and why you should carefully consider sample release criteria based on the post-thaw outcome of quality control (QC) samples