Scaling AAV manufacturing across fixed-bed bioreactors: lessons from Novartis

Gain practical insight into how adeno-associated virus (AAV) production can be scaled from development studies to manufacturing-relevant scale while maintaining process representativeness in both titer and product quality. In this webinar, Novartis scientists share batch-level data illustrating how operating parameters were aligned across development-, intermediate-, and manufacturing-scale fixed-bed bioreactor systems.

The session features Xiang Cui, Senior Manager at Novartis Gene Therapies, who oversees a manufacturing science and technology (MS&T) laboratory supporting GMP production of AAV, and Akash Khorran, Upstream MS&T Engineer, the acting subject matter expert for upstream GMP and lab-scale AAV production. Drawing on their experience supporting gene therapy programs from development through manufacturing scale, they present real, operational data showing how scale-up and scale-down strategies were evaluated during process development.

See comparative results demonstrating consistent trends in cell growth, metabolite profiles, genomic titers, and product impurities across scales. The discussion also highlights which parameters proved critical for maintaining process performance during scale transfer, and how intermediate-scale systems can help reduce development risk and accelerate decision-making ahead of large-scale production.

Watch this webinar to:
• Review batch-level data showing how operating parameters were aligned across development-, intermediate-, and manufacturing-scale fixed-bed bioreactors.
• Understand which parameters proved critical for maintaining consistent AAV titer, cell growth, metabolite trends, and impurity profiles during scale transfer.
• Learn how intermediate-scale systems can support risk reduction and faster decision-making during process development.
• Gain practical guidance on designing scale-down experiments and development studies that remain representative of manufacturing conditions.

For more information about our iCELLis bioreactor family, or to talk to a specialist, head to: https://cytiva.link/mkudr