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Frequent challenges and solutions for SPR assay developers; an R&D perspective

In this tutorial session, we will meet Håkan, Maria, and Lena from the Uppsala-based R&D lab. They have long experience from developing Biacore instruments, applications, and consumables. DiPIA online web conferences have covered how to set-up and validate SPR assays, interpret data, streamline data analysis, and report out. This session will dig deeper and discuss some artefacts and how to address and overcome these to generate data you can trust and base your decisions on. Learn best practices and new recommendations shared straight from the Biacore R&D lab.

Speakers:
Håkan Roos, Principal Engineer, Cytiva
Maria Lindgren,PhD, Scientist, Cytiva
Lena Vinterbäck, Research Engineer, Cytiva

Håkan, a principal engineer, has been working at Cytiva Biacore R&D in Uppsala, Sweden, formerly part of GE Healthcare’s Life Sciences business, since 1987. He has deep knowledge about Biacore technology with special interest in improving sensitivity for all types of applications, especially kinetics, and has been involved in the design of all Biacore systems.
In his daily work, Håkan is currently a lead system designer for hardware, working with specifications and characterization methods, as well as troubleshooting current systems. The latter stems from a profound interest that originates from seven years employment as failure analyst at Philips corporation.

Maria, a Biacore Application Scientist joined the R&D in Uppsala, Sweden four years ago. She has since developed methodology around concentration and potency as well as epitope binning modules for Biacore 8K+. Maria holds a Ph.D. in Biochemistry from Uppsala University and has over 10 years’ experience from the biotech industry, including drug discovery work at Resistentia Pharmaceuticals AB and Beactica AB in Sweden.

Lena, a Staff Research Engineer at the R&D in Uppsala, Sweden, has 20 years’ experience of Biacore consumables.
Previously, she spent 13 years within Pharmacia Diagnostic developing immunoassays. In her current role as project leader, she has been involved in the development of a long range of consumables including Sensor Chip CM7, Sensor Chip Protein A, and kits like the Thiol Coupling Kit and His Capture Kit.