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Holistic in silico process development for antibody formats

In silico chromatography process development with the GoSilico™ chromatography modeling software can speed up PD work and simultaneously improve process understanding.

In this talk, we explore applications of in silico process development (PD) techniques exemplified by a bsAb modeling workflow case study, targeting the removal of product-related impurities from the desired heterodimer during an affinity chromatography step using MabSelect™ VL.

We investigate feasibility and rationality of aggregate removal during capture and showcase how a process model can help understand the impact of upstream variations. Looking forward, we explore further application opportunities of in silico PD in downstream bioprocessing.

Speaker:
Lena Enghauser